Juvenile Pacific salmon (Oncorhynchus spp.), ecologically-related species, and associated environmental (biophysical) data were collected from the marine waters of the northern region of southeastern Alaska in 2010. This annual survey, conducted by the Southeast Coastal Monitoring (SECM) project, marks 14 consecutive years of systematically monitoring how juvenile salmon utilize in marine ecosystems, and was implemented to identify the relationships among biophysical parameters that influence habitat use, marine growth, predation, stock interactions, and year-class strength of juvenile salmon. This report also contrasts the 2010 findings with selected biophysical parameters from the prior 13 sampling years. Up to 13 stations were sampled in epipelagic waters monthly, totaling 21 sampling days, from May to August. Fish, zooplankton, surface water samples, and physical profile data were typically collected during daylight at each station using a surface rope trawl, conical and bongo nets, a water sampler, and a conductivity-temperature-depth profiler. Surface (3-m) temperatures and salinities ranged from approximately 9 to 14 ºC and 17 to 32 PSU from May to August. More than 39,000 fish, representing 26 taxa, were captured in 67 rope trawl hauls fished from June to August. Juvenile salmon comprised about 97% of the total fish catch. Juvenile pink (O. gorbuscha), chum (O. keta), sockeye (O. nerka), and coho (O. kisutch) salmon occurred in 71-87% of the trawls, while juvenile Chinook salmon (O. tshawytscha) occurred in 9% of the hauls. Unusually high numbers of juvenile salmon were captured in strait habitat in both June and July, although CPUE was greatest in June for all species except sockeye salmon. Coded-wire tags were recovered from 15 juvenile coho salmon and one juvenile Chinook salmon from hatchery and wild stocks originating in southeastern Alaska and Washington. Alaska enhanced stocks were also identified by thermal otolith marks from 67% of the chum and 16% of the sockeye salmon examined. Onboard stomach analysis revealed predation on highly abundant juvenile salmon by adult coho salmon, a common predator, and adult pink salmon, a rare predator. Biophysical measures from 2010 differed from prior years, in many respects. May integrated (20-m) temperature anomalies were generally positive and salinity anomalies were generally negative; in particular, the positive May temperature anomaly was the highest on record. Zooplankton monthly total densities were near longterm averages, reversing the trend for strongly positive anomalies over the past four years. For juvenile pink, chum, and sockeye salmon, low condition residuals in June were followed by small size and low energy density in July. Regional biophysical data from SECM are used in conjunction with basin-scale biophysical parameters to forecast pink salmon harvest in southeastern Alaska. Longterm monitoring of key stocks of juvenile salmon, on seasonal and interannual time scales, will enable researchers to understand how growth, abundance, and ecological interactions affect year-class strength of salmon and to better understand their roles in North Pacific marine ecosystems.